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By Blood diagnosed with early stage cancer

Recently, in the "Nature" magazine, researchers expressed protein-coding genes and cancer GPC1 exosomes on, might serve as a potential non-invasive diagnostic and screening tool part for detecting possible yet suitable for surgical treatment in the early stages of pancreatic cancer.

Exosomes is a miniature virus-like particle size secreted by cancer cells, which contains the DNA, RNA and proteins. Researchers have isolated from tBy Blood diagnosed with early stage cancerhe blood of pancreatic cancer patients in the rich GPC1 circulating exosomes --GPC1 + crExos, and its monitoring. Researchers detected in the serum of about 250 pancreatic cancer patients to GPC1 + crExos, and the early and late patient to distinguish patients were significantly decreased patient GPC1 + crExos levels after removal of the tumor. Unlike the circulating tumor cells (CTCs) requires a lot of fresh blood, about 30 years ago to save the blood samples in the freezer can be detected and isolated GPC1 + crExos. It can be extracted from the storage of samples isolated cancer exosomes DNA, RNA and proteins, for further genetic and biological analysis. Thus, not only a exosomes cancer biomarker, they also provide an isolated cancer specific information for us treasure.

Compared to conventional CA 19-9 biomarkers, GPC1 + crExos seems to be a more reliable screening tool. The study found that in a mouse model of pancreatic cancer has not showed signs of when MRI can detect pancreatic disease, GPC1 + crExos is detected the possibility of pancreatic cancer. The researchers said the general population using MRI or CT routine screening for pancreatic cancer, many false positive results, and there may be expensive. The GPC1 + crExos have potential as a pancreatic cancer detection and monitoring tool used in combination with imaging, highlighting its use in the early detection of cancer. If we can diagnose the disease earlier can reduce the mortality rate of pancreatic cancer. This provides an unprecedented opportunity for the early detection of pancreatic cancer and potential treatments designed surgical options.

The researchers said that because of these exosomes can detect pancreatic cancer-specific genetic characteristics, it has great potential to improve the specificity of MRI or CT. If we can diagnose the disease earlier can reduce the mortality rate of pancreatic cancer. This provides an unprecedented opportunity for the early detection of pancreatic cancer and potential treatments designed surgical options.