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The researchers found that aging factors - beta - 2 microglobulin (B2M)

Recently, in the journal Nature Medicine, researchers said they found a pro-aging factor --beta-2-microglobulin (B2M), the molecule inhibits the regenerative capacity of the memory area of the brain cells, making the cognitive decline .

Aging can cause cognitive dysfunction and regeneration of the brain, increasing the likelihood of neurodegeneration. Previously, researchers have found that the use of different methods conjoined, is about young mice and old mice circulatory system linking the blood of young mice aged mice can reverse the decline in learning ability. In the second experiment, the researchers use different methods conjoined found blood aged mice may facilitate the young mouse brain aging. In addition, they found that the circulatory system in these older mice, a pro-aging factor, beta-2-microglobulin (B2M), it is this molecule inhibits the regenerative memory area of the brain cells, causing cognitive decrease power.

B2M is MHC I (major histocompatibility complex class I) is an integral part, MHC I played an important role in the adaptive immune system. At present, more and more studies show, B2M-MHC I complexes present on all cells except red blood cells and plasma cells, however, the role of this complex in the brain is not involved in the immune, but the guide brain development, promote nerve cell communication and influence on behavior-related.

In this study, the researchers first found in the blood of mice B2M levels increased steadily with age. And aged mice connected to the circulatory system of young mice B2M levels are relatively high. The findings in humans has also been confirmed that with age, human blood and cerebrospinal fluid levels of B2M has also been increased. The researchers then injected into the circulatory system will B2M young mice or injected directly into the brain, the results have shown that these mice learning and memory loss, and nerve regeneration is suppressed. However, mice lacking the gene Tap1 (MHC I cell surface expression decreased), or B2M gene knockout, can reduce the cognitive decline and age-related, and enhance nerve regeneration in old mice. These results suggest that, B2M targets is a good antibody or small moleculecompounds for the treatment of cognitive decline caused by the aging.