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Study found that increasing the content of two biomarkers of severe heart diseas

On the magazine Plos One, researchers from the University of North Carolina School of Medicine for the first time to establish a unique animal model and identified in the most severe cases of coronary heart disease of increasing levels of two biomarkers. These two new targets are oxidized low-density lipoprotein cholesterol and glycated proteins. Researchers or further study, and possibly through targeted drugs, insulin resistance help people avoid the worst complications of heart disease.

The researchers said that if insulin resistance in humans, these correlations exist, then the doctor for such patients should be given more attention, because the risk of their developing serious cardiovascular disease is very high. But interestingly, researchers have just started not to find out whether there is a key point biomarkers of insulin resistance in patients with severe heart disease. They want to mimic the human heart disease, animal model of insulin resistance. They chose the pig, this metabolic similar to humans, cardiac structure and function are also human-like animals. Year after the adoption of high fat and salt food to feed all the pigs insulin resistance. In other words, their bodies produce large amounts of insulin, but the cells do not make a normal reaction to the hormone. All pigs also appeared coronary and aortic atherosclerosis complications. However, only about half of the pigs suffering from the most severe heart disease.

When the researchers examined levels of porcine insulin resistance found atherosclerosis severity of insulin resistance and no significant correlation. This is a surprising discovery. Researchers followed by literature known atherosclerotic correlation between hardening and glycoproteins. So they examined the relevant indicators of the level of the pig. Sure enough, the high levels of glycated proteins and oxidized low-density lipoprotein cholesterol points to serious heart attack.

20 severe atherosclerosis pigs have 14 sows. Severe atherosclerosis, atherosclerosis does not appear in 17 pigs, 14 are boars. 2005 Finland has published a study has shown that elevated levels of glycated proteins and malignant progression of heart disease, there is a strong correlation, a higher mortality rate for women under such circumstances, but has little effect on men. The researchers said that the root cause of the correlation is unclear. But now they have a unique animal model to mimic the human disease process. This study of women diet-induced atherosclerosis in women is a good model.

The researchers also said that the next step might be affected heart tissue research, find the cellular pathways glycated protein abnormalities associated with severe coronary artery disease, which may point to potential new therapies or new dietary intervention recommendations.