Industry news

Home > Industry news

Research findings may help elucidate the mechanism of tumor blood vessel growth

Published in the international journal PNAS research paper, researchers from Rice University through research developed a new model, which may help to clarify how the cancerous tumor blood vessel growth to manipulate for their own benefit; as with all cell , tumor cells also require the body to carry oxygen to the blood vessel network and taken out of the cell, and learned how to make tumor angiogenesis for their own services, which allow new blood vessels grow from existing blood vessels, as if the trees are budding same.

The study researchers or the use of sophisticated computer models to detect it conceived the idea; researchers have developed a model that can help reveal the proteins involved in tumor angiogenesis how to communicate with other proteins, but also can reveal tumors use protein signaling Chain control mechanism of blood vessel growth.

The researchers point out that we find a "zigzag" ligand or around the tumor plays an important role in the growth of blood vessels confusion; under normal circumstances, endothelial cells from existing blood vessels "sprout" growth, while the other cells become stem cells that form the blood vessel wall, notch signals between cells that can guide endothelial cells, or stem cells choose to become tip cells. Notch receptor is a protein molecule can bind δ ligands or jagged ligand and its binding mode or may determine the fate of cells.

The researchers said the high-level environment jagged ligand can induce angiogenesis, thus promoting the rapid development of the tumor, but the tumor does not have to wait for the development of blood vessels, which will exploit the vascular structure for their own services; notch-δ pathway had been been widely studied, and the way is a lot of classic anti-angiogenic drugs target, the researchers found that when between cells through jagged ligand to communicate with each other, it will produce a new type of cell that is not angiogenesis tip cells, the stem cells are not.

Damaged cells are the main differences between normal and tumor angiogenesis angiogenesis, if notch- sawtooth signal without affecting the notch-δ premise is suppressed, then it may be able to effectively interfere with tumors; the current anti-angiogenic therapy mainly targeting notch signal, but it will be a lot of side effects, so it is generally not specifically deal with the tumor angiogenesis.

Finally, the researchers say, we have developed a model taking into account the vascular endothelial growth factor (VEGF) effects, VEGF is a protein could induce angiogenesis, and its high level of expression in the state in the blood vessels, so researchers are very grateful Interest is committed to clarify the important mechanism of tumor intercept way, of course, useful for the development of blood vessels is also necessary; later researchers will conduct more in-depth study to the model-based development of new methods of treating cancer.