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Study found that atherosclerosis can cause chronic inflammation

Recently, researchers from London found a network structure, and called neutrophil extracellular traps (NETs). This structure with atherosclerosis in mice, can promote inflammation. NETs is how to form research results and its role in chronic inflammation, etc., published in the latest issue of Science magazine.

As we all know, atherosclerosis is fat or other substances in the arterial wall formed by adhesion and accumulation. Its presence is harmful to health, as this may cause a heart attack or stroke. In this study, researchers used a mouse model of atherosclerosis found that atherosclerosis can also cause chronic inflammation, which is caused by the immune response, including neutrophils and macrophages.

Neutrophils play a very important role in the non-specific immune system, they can resist the invasion of microorganisms. After the neutrophils and microbes continue fighting for some time, the machine experience issue reinforcements signals to histones, DNA content and myeloperoxidase (MPO) enzyme form, support neutrophil elastase, these substances together to form a neutrophil Extracellular Traps (NETs). The researchers found that in a mouse model of atherosclerosis, the cholesterol crystals can trigger the formation of neutrophil NETs. NETs then activates macrophages secrete cytokines, interleukin -1β (IL-1β), thereby activating a helper T cell 17 (TH17), expanded the accumulation of atherosclerotic lesions of immune cells, ultimately resulting in chronic inflammation reaction.

In future studies, the researchers will study in detail the mechanism further NETs formation, and the formation is avoided. Since this study was completed in mouse model of atherosclerosis, the researchers next step will be to conduct a study in human patients, whether the formation of NETs and whether there have the same function.